Article
The chromosome 2p21 region harbors a complex genetic architecture for association with risk for renal cell carcinoma.
Human molecular genetics - 1 Mar 2012
Han Summer S, Yeager Meredith, Moore Lee E, Wei Ming-Hui, Pfeiffer Ruth, Toure Ousmane, Purdue Mark P, Johansson Mattias, Scelo Ghislaine, Chung Charles C, Gaborieau Valerie, Zaridze David, Schwartz Kendra, Szeszenia-Dabrowska Neonilia, Davis Faith, Bencko Vladimir, Colt Joanne S, Janout Vladimir, Matveev Vsevolod, Foretova Lenka, Mates Dana, Navratilova M, Boffetta Paolo, Berg Christine D, Grubb Robert L, Stevens Victoria L, Thun Michael J, Diver W Ryan, Gapstur Susan M, Albanes Demetrius, Weinstein Stephanie J, Virtamo Jarmo, Burdett Laurie, Brisuda Antonin, McKay James D, Fraumeni Joseph F, Chatterjee Nilanjan, Rosenberg Philip S, Rothman Nathaniel, Brennan Paul, Chow Wong-Ho, Tucker Margaret A, Chanock Stephen J, Toro Jorge R
Abstract excerpt
In follow-up of a recent genome-wide association study (GWAS) that identified a locus in chromosome 2p21 associated with risk for renal cell carcinoma (RCC), we conducted a fine mapping analysis of a 120 kb region that includes EPAS1. We genotyped 59 tagged common single-nucleotide polymorphisms (SNPs) in 2278 RCC and 3719 controls of European background and observed a novel signal for rs9679290 [P = 5.75 ×...
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