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Article

Allele-specific cytokine responses at the HLA-C locus: implications for psoriasis.

The Journal of investigative dermatology - 1 Mar 2012

Hundhausen Christian, Bertoni Anna, Mak Rose K, Botti Elisabetta, Di Meglio Paola, Clop Alex, Laggner Ute, Chimenti Sergio, Hayday Adrian C, Barker Jonathan N, Trembath Richard C, Capon Francesca, Nestle Frank O

Abstract excerpt

Psoriasis is an inflammatory skin disorder that is inherited as a complex trait. Genetic studies have repeatedly highlighted HLA-C as the major determinant for psoriasis susceptibility, with the Cw*0602 allele conferring significant disease risk in a wide range of populations. Despite the potential importance of HLA-C variation in psoriasis, either via an effect on peptide presentation or immuno-inhibitory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22113476
DOI: 10.1038/jid.2011.378
PMCID: PMC3620929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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