Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype.

British journal of cancer - 17 Jan 2012

Karihtala P, Kauppila S, Puistola U, Jukkola-Vuorinen A

Abstract excerpt

BACKGROUND: 8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is the most abundant marker of DNA damage and it reflects oxidative stress. Human 8-oxoguanine glycosylase (hOGG1) is a DNA-repair enzyme that participates in 8-oxodG removal. METHODS: hOGG1 protein expression was immunohistochemically studied in 96 patients with local or locally advanced breast cancer and in 20 lesions of non-malignant breast disease....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to DNA Glycosylases
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 22108520
DOI: 10.1038/bjc.2011.518
PMCID: PMC3261678

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype.PMID 22108520Read ↗

Oxidative DNA damage and 8‐hydroxy‐2‐deoxyguanosine DNA glycosylase/apurinic lyase in human breast cancerSemantic proximity Read ↗

Genetic polymorphism in hOGG1 is associated with triple-negative breast cancer risk in Chinese Han women.Semantic proximity Read ↗

Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.Semantic proximity Read ↗

Two functional variations in 5'-UTR of hoGG1 gene associated with the risk of breast cancer in Chinese.Semantic proximity Read ↗

Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA.Semantic proximity Read ↗

DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326.Semantic proximity Read ↗

Genetic polymorphism of hOGG1 ser326cys and its association with breast cancer in Jammu and Kashmir.Semantic proximity Read ↗

OGG1 polymorphisms and breast cancer risk.Semantic proximity Read ↗

Overexpression of the hOGG1 gene and high 8-hydroxy-2'-deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: regulation mechanism of the 8-OHdG level in DNA.Semantic proximity Read ↗

Ser326Cys polymorphism in DNA repair genes hOGG1 in breast cancer women.Semantic proximity Read ↗

Association between polymorphism of human oxoguanine glycosylase 1 and risk of prostate cancer.Semantic proximity Read ↗

Functional polymorphisms of the hOGG1 gene confer risk to type 2 epithelial ovarian cancer in Chinese.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.