Article
Genetic polymorphism of hOGG1 ser326cys and its association with breast cancer in Jammu and Kashmir.
Indian journal of cancer - 1 Jan 2000
Nagpal Ashna, Verma Sonali, Shah Ruchi, Bhat Ghulam R, Bhat Amrita, Bakshi Divya, Sharma Bhanu, Kaul Sandeep, Kumar Rakesh
Abstract excerpt
BACKGROUND: 8-Oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodG) is a potent DNA damage marker that leads to cellular oxidative stress. It is a DNA-repair enzyme that participates in "8-oxodG" DNA adducts removal. Previous studies show weak associations of rs1052133 (hOGG1) in breast cancer patients of Northern India. We performed this study to explore the variant rs1052133 (hOGG1) with breast in the population of...
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