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Article

Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 1997

Radicella J P, Dherin C, Desmaze C, Fox M S, Boiteux S

Abstract excerpt

The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase activity that is a functional analog of the Fpg protein from Escherichia coli and excises 7,8-dihydro-8-oxoguanine (8-oxoG) from damaged DNA. The repair of this ubiquitous kind of oxidative damage is essential to prevent mutations both in bacteria and in yeast. A human cDNA clone carrying an ORF displaying homology to the yeast protein was...

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Identifiers

PMID: 9223305
DOI: 10.1073/pnas.94.15.8010
PMCID: PMC21547

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.PMID 9223305Read ↗

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Catalytic and DNA-binding properties of the human Ogg1 DNA N-glycosylase/AP lyase: biochemical exploration of H270, Q315 and F319, three amino acids of the 8-oxoguanine-binding pocket.Semantic proximity Read ↗

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