Article
Clinical implications of non-A-type NPM1 and FLT3 mutations in patients with normal karyotype acute myeloid leukemia.
Acta haematologica - 1 Jan 2012
Park Borae G, Chi Hyun-Sook, Park Seo-Jin, Min Sook Kyoung, Jang Seongsoo, Park Chan-Jeoung, Kim Dae-Young, Lee Jung-Hee, Lee Je-Hwan, Lee Kyoo-Hyung
Abstract excerpt
Mutations in the nucleophosmin (NPM1) and fms-like tyrosine kinase-3 (FLT3) genes are the most commonly observed mutations in patients with normal-karyotype acute myeloid leukemia (AML-NK). We analyzed the prognostic effects and interactions of these mutations in 201 AML-NK patients. NPM1 and FLT3 mutations were found in 38.3 and 24.9% of AML-NK patients, respectively. NPM1 mutations (NPM1mut), especially in...
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