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Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype

27 Jul 2005

Abstract excerpt

Mutation of the nucleophosmin (NPM) gene has been reported as the most frequent mutation in acute myeloid leukemia (AML), especially in the presence of a normal karyotype. In this subgroup of intermediate-risk AML, the identification of other gene mutations (eg, FLT3, CCAAT/enhancer-binding protein-alpha [CEBPA]) has helped to refine the prognosis. This study explored the prevalence and the prognostic impact of...

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PMID: 16046528
DOI: 10.1182/blood-2005-05-2174

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