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Article

Effect of NPM1 and FLT3 mutations on the outcomes of elderly patients with acute myeloid leukemia receiving standard chemotherapy.

Clinical lymphoma, myeloma & leukemia - 1 Aug 2013

Daver Naval, Liu Dumlao Theresa, Ravandi Farhad, Pierce Sherry, Borthakur Gautam, Pemmaraju Naveen, Nazha Aziz, Faderl Stefan, Jabbour Elias, Garcia-Manero Guillermo, Cortes Jorges, Kantarjian Hagop, Quintás-Cardama Alfonso

Abstract excerpt

BACKGROUND: The effect of prognostically important gene mutations (MUTs), nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1) and fms-related tyrosine kinase 3 (FLT3), in elderly patients with acute myeloid leukemia (AML) is not well defined. PATIENTS AND METHODS: We analyzed 557 patients, 65 years of age or older with newly diagnosed AML, treated at our institution between 2000 and 2010 with cytotoxic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23763915
DOI: 10.1016/j.clml.2013.02.021
PMCID: PMC4114766

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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