A Sequential splicing mechanism promotes selection of an optimal exon by repositioning a downstream 5' splice site in preprotachykinin pre-mRNA.

doi:10.1101/gad.4.7.1172

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Article

A Sequential splicing mechanism promotes selection of an optimal exon by repositioning a downstream 5' splice site in preprotachykinin pre-mRNA.

Genes & development - 1 Jul 1990

Nasim F H, Spears P A, Hoffmann H M, Kuo H C, Grabowski P J

Abstract excerpt

To explore the structural basis of alternative splicing, we have analyzed the splicing of pre-mRNAs containing an optional exon, E4, from the preprotachykinin gene. This gene encodes substance P and related tachykinin peptides by alternative splicing of a common pre-mRNA. We have shown that alter...

Topics

Base Sequence
Exons
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Protein Precursors
RNA Precursors
RNA Splicing
RNA, Messenger
Tachykinins

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