Article
Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells.
Journal of proteome research - 3 Feb 2012
Ferreira Gabriela Bomfim, Kleijwegt Fleur S, Waelkens Etienne, Lage Kasper, Nikolic Tatjana, Hansen Daniel Aaen, Workman Christopher T, Roep Bart O, Overbergh Lut, Mathieu Chantal
Abstract excerpt
Tolerogenic dendritic cells (DC) that are maturation-resistant and locked in a semimature state are promising tools in clinical applications for tolerance induction. Different immunomodulatory agents have been shown to induce a tolerogenic DC phenotype, such as the biologically active form of vitamin D (1,25(OH)(2)D(3)), glucocorticoids, and a synergistic combination of both. In this study, we aimed to...
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