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Article

Identification of Profound Metabolic Alterations in Human Dendritic Cells by Progesterone Through Integrated Bioinformatics Analysis.

Frontiers in immunology - 1 Jan 2021

Zhang Sainan, Liu Su, Hong Ling, Wang Xiaohui, Diao Lianghui, Cai Songchen, Yin Tailang, Zeng Yong

Abstract excerpt

Maintaining the homeostasis of the decidual immune microenvironment at the maternal-fetal interface is essential for reproductive success. Dendritic cells (DCs) are the professional antigen-presenting cells and dominate this balance of immunogenicity and tolerance. Progesterone (P4) is highlighted as the "hormone of pregnancy" in most eutherian mammals because of its regulatory role in immune-endocrine behavior...

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Identifiers

PMID: 34975920
DOI: 10.3389/fimmu.2021.806110
PMCID: PMC8718397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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