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Article

Creation of bioorthogonal redox systems depending on nicotinamide flucytosine dinucleotide.

Journal of the American Chemical Society - 28 Dec 2011

Ji Debin, Wang Lei, Hou Shuhua, Liu Wujun, Wang Jinxia, Wang Qian, Zhao Zongbao K

Abstract excerpt

Many enzymes catalyzing biological redox chemistry depend on the omnipresent cofactor, nicotinamide adenine dinucleotide (NAD). NAD is also involved in various nonredox processes. It remains challenging to disconnect one particular NAD-dependent reaction from all others. Here we present a bioorthogonal system that catalyzes the oxidative decarboxylation of l-malate with a dedicated abiotic cofactor, nicotinamide...

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PMID: 22098020
DOI: 10.1021/ja2074032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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