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Engineering Escherichia coli Nicotinic Acid Mononucleotide Adenylyltransferase for Fully Active Amidated NAD Biosynthesis.

Applied and environmental microbiology - 1 Jul 2017

Wang Xueying, Zhou Yongjin J, Wang Lei, Liu Wujun, Liu Yuxue, Peng Chang, Zhao Zongbao K

Abstract excerpt

NAD and its reduced form NADH function as essential redox cofactors and have major roles in determining cellular metabolic features. NAD can be synthesized through the deamidated and amidated pathways, for which the key reaction involves adenylylation of nicotinic acid mononucleotide (NaMN) and nicotinamide mononucleotide (NMN), respectively. In Escherichia coli, NAD de novo biosynthesis depends on the protein...

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PMID: 28455340
DOI: 10.1128/AEM.00692-17
PMCID: PMC5478990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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