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Article

Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria.

Science (New York, N.Y.) - 18 Nov 2011

Nguyen Dao, Joshi-Datar Amruta, Lepine Francois, Bauerle Elizabeth, Olakanmi Oyebode, Beer Karlyn, McKay Geoffrey, Siehnel Richard, Schafhauser James, Wang Yun, Britigan Bradley E, Singh Pradeep K

Abstract excerpt

Bacteria become highly tolerant to antibiotics when nutrients are limited. The inactivity of antibiotic targets caused by starvation-induced growth arrest is thought to be a key mechanism producing tolerance. Here we show that the antibiotic tolerance of nutrient-limited and biofilm Pseudomonas aeruginosa is mediated by active responses to starvation, rather than by the passive effects of growth arrest. The...

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Identifiers

PMID: 22096200
DOI: 10.1126/science.1211037
PMCID: PMC4046891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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