Article
Explorative gene analysis of antibiotic tolerance-related genes in adherent and biofilm cells of Pseudomonas aeruginosa.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 May 2017
Murakami Keiji, Ono Tsuneko, Noma Yasuki, Minase Issei, Amoh Takashi, Irie Yasuhiko, Hirota Katsuhiko, Miyake Yoichiro
Abstract excerpt
BACKGROUND: Antibiotic tolerance has attracted worldwide attention, as it leads to chronic, refractory, and persistent infections that are difficult to control. Bacterial biofilms are well known to be more tolerant to antibiotics compared to planktonic bacteria. We previously revealed that adherent bacteria on a solid surface also exhibited tolerance to antibiotics before forming a biofilm. However, little is...
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