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Article

Fluorescence detection of single-nucleotide polymorphism with single-strand triplex-forming DNA probes.

Chembiochem : a European journal of chemical biology - 16 Dec 2011

Li Xinpeng, Wang Yuan, Guo Jiajie, Tang Xinjing

Abstract excerpt

Triple-helix-forming oligonucleotides (TFOs) are widespread in the genome and have been found in regulatory regions, especially in promoter zones and recombination hotspots of DNA. To specifically detect these polypurine sequences, we designed and synthesized two dual pyrene-labeled single-strand oligonucleotide probes (TFO-FPs) consisting of recognition, linker, and detection sequences. The hybridization...

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PMID: 22095630
DOI: 10.1002/cbic.201100534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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