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Article

Pyrene-functionalized triazole-linked 2'-deoxyuridines-probes for discrimination of single nucleotide polymorphisms (SNPs).

Chemical communications (Cambridge, England) - 21 Jul 2010

Østergaard Michael E, Guenther Dale C, Kumar Pawan, Baral Bharat, Deobald Lee, Paszczynski Andrzej J, Sharma Pawan K, Hrdlicka Patrick J

Abstract excerpt

Oligonucleotides modified with pyrene-functionalized triazole-linked 2'-deoxyuridines display remarkable hybridization-induced increases in fluorescence emission and enable efficient fluorescent discrimination of SNPs via G-specific quenching.

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Identifiers

PMID: 20526503
DOI: 10.1039/c0cc01133a

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