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Article

Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes.

Diabetologia - 1 Feb 2012

Snogdal L S, Wod M, Grarup N, Vestmar M, Sparsø T, Jørgensen T, Lauritzen T, Beck-Nielsen H, Henriksen J E, Pedersen O, Hansen T, Højlund K

Abstract excerpt

AIMS/HYPOTHESIS: There is substantial evidence that mitochondrial dysfunction is linked to insulin resistance and is present in several tissues relevant to the pathogenesis of type 2 diabetes. Here, we examined whether common variation in genes involved in oxidative phosphorylation (OxPhos) contributes to type 2 diabetes susceptibility or influences diabetes-related metabolic traits. METHODS: OxPhos gene variants...

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Identifiers

PMID: 22095239
DOI: 10.1007/s00125-011-2377-0

Genes

COX10
UQCRC1

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