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Contribution of mitochondrial gene variants in diabetes and diabetic kidney disease

12 Oct 2022

Abstract excerpt

Objectives: Mitochondrial DNA (mtDNA) plays an important role in the pathogenesis of diabetes. Variants in mtDNA have been reported in diabetes, but studies on the whole mtDNA variants were limited. Our study aims to explore the association of whole mtDNA variants with diabetes and diabetic kidney disease (DKD). Methods: The whole mitochondrial genome was screened by next-generation sequencing in cohort 1...

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PMID: 36313763
DOI: 10.3389/fendo.2022.953631

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