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Article

Microfludic device for creating ionic strength gradients over DNA microarrays for efficient DNA melting studies and assay development.

PloS one - 1 Jan 2009

Petersen Jesper, Poulsen Lena, Birgens Henrik, Dufva Martin

Abstract excerpt

The development of DNA microarray assays is hampered by two important aspects: processing of the microarrays is done under a single stringency condition, and characteristics such as melting temperature are difficult to predict for immobilized probes. A technical solution to these limitations is to use a thermal gradient and information from melting curves, for instance to score genotypes. However, application of...

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PMID: 19277213
DOI: 10.1371/journal.pone.0004808
PMCID: PMC2653225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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