Microarrays assembled in microfluidic chips fabricated from poly(methyl methacrylate) for the detection of low-abundant DNA mutations.

doi:10.1021/ac020683w

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Article

Microarrays assembled in microfluidic chips fabricated from poly(methyl methacrylate) for the detection of low-abundant DNA mutations.

Analytical chemistry - 1 Mar 2003

Wang Yun, Vaidya Bikas, Farquar Hannah D, Stryjewski Wieslaw, Hammer Robert P, McCarley Robin L, Soper Steven A, Cheng Yu-Wei, Barany Francis

Abstract excerpt

Low-density arrays were assembled into microfluidic channels hot-embossed in poly(methyl methacrylate) (PMMA) to allow the detection of low-abundant mutations in gene fragments (K-ras) that carry point mutations with high diagnostic value for colorectal cancers. Following spotting, the chip was assembled with a cover plate and the array accessed using microfluidics in order to enhance the kinetics associated with...

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PMID: 12641233
DOI: 10.1021/ac020683w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.