Article
Plastic biochannel hybridization devices: a new concept for microfluidic DNA arrays.
Analytical biochemistry - 1 Dec 2002
Lenigk Ralf, Liu Robin H, Athavale Mahesh, Chen Zhijian, Ganser Dale, Yang Jianing, Rauch Cory, Liu Yingjie, Chan Betty, Yu Huinan, Ray Melissa, Marrero Robert, Grodzinski Piotr
Abstract excerpt
Conventional DNA hybridization assay kinetics depends solely on the diffusion of target to surface-bound probes, causing long hybridization times. In this study, we examined the possibilities of accelerating the hybridization process by using microfluidic channels ("biochannels") made of polycarbonate, optionally with an integrated pump. We produced two different devices to study these effects: first,...
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