Article
Dopamine D₃ receptor gene variation: impact on electroconvulsive therapy response and ventral striatum responsiveness in depression.
The international journal of neuropsychopharmacology - 1 Aug 2013
Dannlowski Udo, Domschke Katharina, Birosova Eva, Lawford Bruce, Young Ross, Voisey Joanne, Morris C Phillip, Suslow Thomas, Konrad Carsten, Kugel Harald, Ohrmann Patricia, Bauer Jochen, Schöning Sonja, Zavorotnyy Maxim, Diemer Julia, Arolt Volker, Baune Bernhard T, Zwanzger Peter
Abstract excerpt
Dysfunction of dopamine D₃ receptors, particularly in the mesocorticolimbic system, has been linked to the pathogenesis of major depression. Preclinical data show enhanced D₃ receptor binding in the striatum upon antidepressant medication and electroconvulsive therapy (ECT). Thus, the potential impact of dopamine D₃ receptor gene (DRD3) variation on ECT outcome in treatment-resistant major depression was...
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