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Article

Epigenetic regulation of p62/SQSTM1 overcomes the radioresistance of head and neck cancer cells via autophagy-dependent senescence induction

5 Mar 2021

Abstract excerpt

Tumors are composed of subpopulations of cancer cells with functionally distinct features. Intratumoral heterogeneity limits the therapeutic effectiveness of cancer drugs. To address this issue, it is important to understand the regulatory mechanisms driving a subclonal variety within a therapy-resistant tumor. We identified tumor subclones of HN9 head and neck cancer cells showing distinct responses to radiation...

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Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
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PMID: 33674559
DOI: 10.1038/s41419-021-03539-5

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