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Article

Alpha1a-adrenoceptor genetic variant induces cardiomyoblast-to-fibroblast-like cell transition via distinct signaling pathways.

Cellular signalling - 1 Sept 2014

Kleine-Brueggeney Maren, Gradinaru Irina, Babaeva Ekaterina, Schwinn Debra A, Oganesian Anush

Abstract excerpt

The role of naturally occurring human α1a-Adrenergic Receptor (α1aAR) genetic variants associated with cardiovascular disorders is poorly understood. Here, we present the novel findings that expression of human α1aAR-247R (247R) genetic variant in cardiomyoblasts leads to transition of cardiomyoblasts into a fibroblast-like phenotype, evidenced by morphology and distinct de novo expression of characteristic...

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Identifiers

PMID: 24835978
DOI: 10.1016/j.cellsig.2014.05.007
PMCID: PMC4305345

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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