Article
G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor.
The Journal of biological chemistry - 15 Jul 2005
Mifune Mizuo, Ohtsu Haruhiko, Suzuki Hiroyuki, Nakashima Hidekatsu, Brailoiu Eugen, Dun Nae J, Frank Gerald D, Inagami Tadashi, Higashiyama Shigeki, Thomas Walter G, Eckhart Andrea D, Dempsey Peter J, Eguchi Satoru
Abstract excerpt
A G protein-coupled receptor agonist, angiotensin II (AngII), induces epidermal growth factor (EGF) receptor (EGFR) transactivation possibly through metalloprotease-dependent, heparin-binding EGF (HB-EGF) shedding. Here, we have investigated signal transduction of this process by using COS7 cells expressing an AngII receptor, AT1. In these cells AngII-induced EGFR transactivation was completely inhibited by...
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