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Article

Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Mar 2005

Lei Beilei, Morris Daniel P, Smith Michael P, Svetkey Laura P, Newman Mark F, Rotter Jerome I, Buchanan Thomas A, Beckstrom-Sternberg Stephen M, Green Eric D, Schwinn Debra A

Abstract excerpt

We identified nine naturally-occurring human single nucleotide polymorphisms (SNPs) in the alpha(1a)-adrenoceptor (alpha(1a)AR) coding region, seven of which result in amino acid change. Utilizing rat-1 fibroblasts stably expressing wild type alpha(1a)AR or each SNP at both high and low levels, we investigated the effect of these SNPs on receptor function. Compared with wild type, two SNPs (R166K, V311I) cause a...

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Identifiers

PMID: 15900517
DOI: 10.1007/s00210-005-1019-9
PMCID: PMC2367253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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