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Article

The pharmacogenetics and pharmacodynamics of clopidogrel response: an analysis from the PRINC (Plavix Response in Coronary Intervention) trial.

JACC. Cardiovascular interventions - 1 Dec 2008

Gladding Patrick, Webster Mark, Zeng Irene, Farrell Helen, Stewart Jim, Ruygrok Peter, Ormiston John, El-Jack Seif, Armstrong Guy, Kay Patrick, Scott Douglas, Gunes Arzu, Dahl Marja-Liisa

Abstract excerpt

OBJECTIVES: This study assessed the effect of pharmacogenetics on the antiplatelet effect of clopidogrel. BACKGROUND: Variability in clopidogrel response might be influenced by polymorphisms in genes coding for drug metabolism enzymes (cytochrome P450 [CYP] family), transport proteins (P-glycoprotein) and/or target proteins for the drug (adenosine diphosphate-receptor P2Y12). METHODS: Sixty patients undergoing...

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Source

Identifiers

PMID: 19463375
DOI: 10.1016/j.jcin.2008.09.008

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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