Where is the causal variant? On the advantage of the family design over the case-control design in genetic association studies.

Abstract excerpt

Many associated single-nucleotide polymorphisms (SNPs) have been identified by association studies for numerous diseases. However, the association between a SNP and a disease can result from a causal variant in linkage disequilibrium (LD) with the considered SNP. Assuming that the true causal variant is among the genotyped SNPs, other authors demonstrated that the power to discriminate between it and other SNPs...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bayes Theorem
• Share to Family
• Share to Genetic Association Studies