Article
Risk alleles for multiple sclerosis identified by a genomewide study.
The New England journal of medicine - 30 Aug 2007
Hafler David A, Compston Alastair, Sawcer Stephen, Lander Eric S, Daly Mark J, De Jager Philip L, de Bakker Paul I W, Gabriel Stacey B, Mirel Daniel B, Ivinson Adrian J, Pericak-Vance Margaret A, Gregory Simon G, Rioux John D, McCauley Jacob L, Haines Jonathan L, Barcellos Lisa F, Cree Bruce, Oksenberg Jorge R, Hauser Stephen L
Abstract excerpt
BACKGROUND: Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis. METHODS: We used DNA microarray technology to identify common DNA sequence variants in 931 family trios (consisting of an affected child and both parents) and tested them for association. For replication, we genotyped...
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