Article
Variation in number of cagA EPIYA-C phosphorylation motifs between cultured Helicobacter pylori and biopsy strain DNA.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2012
Karlsson Anneli, Ryberg Anna, Nosouhi Dehnoei Marjan, Borch Kurt, Monstein Hans-Jürg
Abstract excerpt
The Helicobacter pylori cagA gene encodes a cytotoxin which is activated by phosphorylation after entering the host epithelial cell. Phosphorylation occurs on specific tyrosine residues within EPIYA motifs in the variable 3'-region. Four different cagA EPIYA motifs have been defined according to...
Topics
- Amino Acid Motifs
- Antigens, Bacterial
- Bacterial Proteins
- Bacterial Typing Techniques
- Biopsy
- Cloning, Molecular
- DNA, Bacterial
- Genotype
- Helicobacter Infections
- Helicobacter pylori
- Humans
- Phosphorylation
- Protein Structure, Tertiary
- Sequence Analysis, DNA
- Specimen Handling
- Virulence