Article
Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms.
Gastroenterology - 1 Jul 2008
Basso Daniela, Zambon Carlo-Federico, Letley Darren P, Stranges Alessia, Marchet Alberto, Rhead Joanne L, Schiavon Stefania, Guariso Graziella, Ceroti Marco, Nitti Donato, Rugge Massimo, Plebani Mario, Atherton John C
Abstract excerpt
BACKGROUND & AIMS: The Helicobacter pylori gene cagA and s1 or m1 forms of vacA are more common in disease-associated strains. Recently, forms of cagA encoding multiple type C EPIYA segments (which increase phosphorylation-dependent CagA activity) and a new type i1 "intermediate region" polymorphism in vacA (which confers toxicity) have been described. We assessed the association of new and established cagA and...
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