Amino acid polymorphisms flanking the EPIYA-A motif of Helicobacter pylori CagA C-terminal region is associated with gastric cancer in east China: experience from a single center.

doi:10.1111/1751-2980.12056

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Article

Amino acid polymorphisms flanking the EPIYA-A motif of Helicobacter pylori CagA C-terminal region is associated with gastric cancer in east China: experience from a single center.

Journal of digestive diseases - 1 Jul 2013

Chen Chun Yan, Wang Fang Yu, Wan Hai Jun, Jin Xin Xin, Wei Juan, Wang Zhen Kai, Liu Chang, Lu Heng, Shi Hui, Li Dong Hai, Liu Jiong

Abstract excerpt

OBJECTIVE: The study aimed to investigate the relationship between gastroduodenal disease and the diversity of the cagA 3' variable region and the amino acid polymorphisms in the Glu-Pro-Ile-Tyr-Ala (EPIYA) segments of the CagA C-terminal region of Helicobacter pylori (H. pylori). METHODS: Gastric mucosal specimens from 170 patients in our center (Nanjing, Jiangsu Province, China) were collected and the genomic...

Topics

Adult
Amino Acid Motifs
Amino Acid Sequence
Amino Acid Substitution
Antigens, Bacterial
Bacterial Proteins
China
Chronic Disease
Duodenal Ulcer
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gastritis

Genes, Bacterial

Genetic Variation

Helicobacter Infections

Helicobacter pylori

Humans

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 23517408
DOI: 10.1111/1751-2980.12056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23517408-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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