CagA phosphorylation EPIYA-C motifs and the vacA i genotype in Helicobacter pylori strains of asymptomatic children from a high-risk gastric cancer area in northeastern Brazil.

doi:10.1590/0074-0276140279

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CagA phosphorylation EPIYA-C motifs and the vacA i genotype in Helicobacter pylori strains of asymptomatic children from a high-risk gastric cancer area in northeastern Brazil.

Memorias do Instituto Oswaldo Cruz - 1 Dec 2014

Braga Lucia Libanez Bessa Campelo, Oliveira Maria Aparecida Alves de, Gonçalves Maria Helane Rocha Batista, Chaves Fernando Kennedy, Benigno Tiago Gomes da Silva, Gomes Adriana Dias, Silva Cícero Igor Simões Moura, Anacleto Charles, Batista Sérgio de Assis, Queiroz Dulciene Maria Magalhães

Abstract excerpt

Helicobacter pylori infection is one of the most common infections worldwide and is associated with gastric diseases. Virulence factors such as VacA and CagA have been shown to increase the risk of these diseases. Studies have suggested a causal role of CagA EPIYA-C in gastric carcinogenesis and this factor has been shown to be geographically diverse. We investigated the number of CagA EPIYA motifs and the vacA i...

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PMID: 25494468
DOI: 10.1590/0074-0276140279
PMCID: PMC4325609

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