Article
Analysis of 3'-end variable region of the cagA gene in Helicobacter pylori isolated from Iranian population.
Journal of gastroenterology and hepatology - 1 Jan 2010
Shokrzadeh Leila, Baghaei Kaveh, Yamaoka Yoshio, Dabiri Hossein, Jafari Fereshteh, Sahebekhtiari Navid, Tahami Ali, Sugimoto Mitsushige, Zojaji Homayon, Zali Mohammad Reza
Abstract excerpt
BACKGROUND AND AIMS: The 3' region of the cagA gene, the most well-known virulence factor of Helicobacter pylori, contains Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs. Four segments flanking the EPIYA motifs, EPIYA-A, -B, -C, or -D, were reported to play important roles in H. pylori-related gastroduodenal pathogenesis. The aim was to determine the roles of EPIYA segments in gastroduodenal pathogenesis in an Iranian...
Topics
- Adult
- Amino Acid Motifs
- Amino Acid Sequence
- Antigens, Bacterial
- Asian People
- Bacterial Proteins
- Dyspepsia
- Female
- Genotype
- Helicobacter Infections