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Article

Distinct <i>cagA</i> EPIYA Motifs are Associated with Ethnic Diversity in Malaysia and Singapore

23 Jul 2009

Abstract excerpt

BACKGROUND: In vitro studies have shown that the biologic activity of CagA is influenced by the number and class of EPIYA motifs present in its variable region as these motifs correspond to the CagA phosphorylation sites. It has been hypothesized that strains possessing specific combinations of these motifs may be responsible for gastric cancer development. This study investigated the prevalence of cagA and the...

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PMID: 19674129
DOI: 10.1111/j.1523-5378.2009.00684.x

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