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Article

Characterization of a mutant R11H αB-crystallin associated with human inherited cataract.

Biological chemistry - 1 Dec 2010

Chen Qiang, Yan Ming, Xiang Feiyan, Zhou Xin, Liu Yuanyuan, Zheng Fang

Abstract excerpt

αB-Crystallin plays an important part in cataract development. A novel mutation (R11H) was previously detected by our group. In the present study, we set out to investigate the possible molecular mechanism by which the R11H mutation causes cataract. We found that the mutant αB-crystallin exhibits folding defects, decreased surface hydrophobicity and enhanced chaperone-like activity compared with the wild-type...

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Identifiers

PMID: 21087083
DOI: 10.1515/BC.2010.143

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Characterization of a mutant R11H αB-crystallin associated with human inherited cataract.PMID 21087083Read ↗

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