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Article

Cataract-causing variant Q70P damages structural stability of βB1-crystallin and increases its tendency to form insoluble aggregates.

International journal of biological macromolecules - 1 Jul 2023

Zhang Ying, Ren Ling, Wu Wei, Liu Jian, Tian Qing, Yao Ke, Yu Yibo, Hu Lidan, Chen Xiangjun

Abstract excerpt

Congenital cataract is the primary cause of childhood blindness worldwide. As the predominant structural protein, βB1-crystallin plays an important role in maintaining lens transparency and cellular homeostasis. Numerous cataract-causing mutations of βB1-crystallin have been identified with unclear pathogenic mechanism. We previously identified the mutation Q70P (Q to P at residue position 70) of βB1-crystallin...

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Identifiers

PMID: 37148932
DOI: 10.1016/j.ijbiomac.2023.124722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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