Article
Modeling rotavirus strain dynamics in developed countries to understand the potential impact of vaccination on genotype distributions.
Proceedings of the National Academy of Sciences of the United States of America - 29 Nov 2011
Pitzer Virginia E, Patel Manish M, Lopman Ben A, Viboud Cécile, Parashar Umesh D, Grenfell Bryan T
Abstract excerpt
Understanding how immunity shapes the dynamics of multistrain pathogens is essential in determining the selective pressures imposed by vaccines. There is currently much interest in elucidating the strain dynamics of rotavirus to determine whether vaccination may lead to the replacement of vaccine-type strains. In developed countries, G1P[8] strains constitute the majority of rotavirus infections most years, but...
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