Article
Did Large-Scale Vaccination Drive Changes in the Circulating Rotavirus Population in Belgium?
Scientific reports - 21 Dec 2015
Pitzer Virginia E, Bilcke Joke, Heylen Elisabeth, Crawford Forrest W, Callens Michael, De Smet Frank, Van Ranst Marc, Zeller Mark, Matthijnssens Jelle
Abstract excerpt
Vaccination can place selective pressures on viral populations, leading to changes in the distribution of strains as viruses evolve to escape immunity from the vaccine. Vaccine-driven strain replacement is a major concern after nationwide rotavirus vaccine introductions. However, the distribution of the predominant rotavirus genotypes varies from year to year in the absence of vaccination, making it difficult to...
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