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Article

Cooperative effect of GNB3 825C>T and GPIIIa PI(A) polymorphisms in enhanced platelet aggregation.

Thrombosis research - 15 Mar 2003

Frey Ulrich H, Aral Nese, Müller Norbert, Siffert Winfried

Abstract excerpt

INTRODUCTION: Platelet aggregation contributes to various thrombembolic disorders. Environmental factors affect platelet aggregability but only partially explain the interindividual variability in aggregation. While the platelet glycoprotein IIb/IIIa is involved in the pathogenesis of acute coronary syndromes whereas most platelet activating stimuli act via G Protein coupled receptors we investigated whether the...

Topics

Adult
Alleles
Epinephrine
Female
Genetic Predisposition to Disease
Genotype
Heterotrimeric GTP-Binding Proteins
Humans
Integrin beta3
Male
Platelet Aggregation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Thrombophilia

Source

Identifiers

PMID: 12818251
DOI: 10.1016/s0049-3848(03)00253-6

Genes

GNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12818251-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Cooperative effect of GNB3 825C>T and GPIIIa PI(A) polymorphisms in enhanced platelet aggregation.PMID 12818251Read ↗

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