Article
A murine model for B-cell lymphomagenesis in immunocompromised hosts: c-myc-rearranged B-cell lines with a premalignant phenotype.
Cancer research - 1 Nov 1990
Felsher D W, Denis K A, Weiss D, Ando D T, Braun J
Abstract excerpt
Activation of c-myc or bcl-2 protooncogene is a common event in B-cell lymphomagenesis. Alone, each is insufficient to produce lymphoma, prompting the search for the additional steps required to complete the malignant phenotype. Among the existing systems of murine or human B-cell neoplasia, no c...
Topics
- Animals
- B-Lymphocytes
- Cell Line
- Disease Models, Animal
- Female
- Gene Rearrangement, B-Lymphocyte
- Genes, myc
- Immunocompetence
- Lymphoma, B-Cell
- Male
- Mice
- Mice, Inbred BALB C