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Article

Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis.

Infection and immunity - 1 May 2002

Ewann Fanny, Jackson Mary, Pethe Kevin, Cooper Andrea, Mielcarek Nathalie, Ensergueix Danielle, Gicquel Brigitte, Locht Camille, Supply Philip

Abstract excerpt

Adaptive regulation of gene expression in response to environmental changes is a general property of bacterial pathogens. By screening an ordered transposon mutagenesis library of Mycobacterium tuberculosis, we have identified three mutants containing a transposon in the coding sequence or in the 5' regions of genes coding for two-component signal transduction systems (trcS, regX3, prrA). The intracellular...

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Identifiers

PMID: 11953357
DOI: 10.1128/IAI.70.5.2256-2263.2002
PMCID: PMC127906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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