Comparative transcriptomics reveals PrrAB-mediated control of metabolic, respiration, energy-generating, and dormancy pathways in Mycobacterium smegmatis

Abstract excerpt

<title>Abstract</title> <p>Background Mycobacterium smegmatis is a saprophytic bacterium frequently used as a genetic surrogate to study pathogenic Mycobacterium tuberculosis. The PrrAB two-component genetic regulatory system is essential in M. tuberculosis and represents an attractive therapeutic target. In this study, transcriptomic analysis (RNA-seq) of an M. smegmatis ΔprrAB mutant was used to define the PrrA...

Topics

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• Gene Expression Profiling
• Gene Expression Regulation, Bacterial
• Gene Expression Regulation, Developmental
• Gene Regulatory Networks
• Genetic Complementation Test
• Mycobacterium smegmatis
• Regulon
• Sequence Analysis, RNA

Identifiers and source

Literature Corpus work

7a12fcc7-5dae-5c13-81b1-56af746dfe8c

DOI

10.21203/rs.2.9596/v3