Article
Mitochondrial DNA modulation of the anchorage-independent phenotype of transformed avian cells.
Cancer research - 15 Oct 1990
Zinkewich-Péotti K, Parent M, Morais R
Abstract excerpt
The progressive loss of mitochondrial DNA in the presence of ethidium bromide in immortal avian cell lines correlates with a decrease in their potential for anchorage-independent growth in soft agar. In short-term treated cells, this effect is reversible and the recovery of cloning potential parallels the recovery of control levels of mitochondrial DNA. Long-term ethidium-bromide-treated cells are permanently...
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