Article
On the tumorigenicity of mitochondrial DNA-depleted avian cells.
Cancer letters - 1 Aug 1991
Zinkewich-Péotti K, Parent M, Morais R
Abstract excerpt
We have examined the tumorigenic potential of mitochondrial DNA-depleted (mtDNA-) cells derived from the tumorigenic chicken cell line DU24. The mtDNA- cells were unable to proliferate in the wing web of day-old chicks. Cytoplasmic hybrids resulting from crosses between the mtDNA- whole cells and cytoplasts from enucleated parental cells (mtDNA+) recover both mtDNA and tumorigenicity. These results are in...
Topics
- Animals
- Cell Division
- Cell Line
- Chickens
- DNA, Mitochondrial
- Hybrid Cells
- Neoplasms, Experimental
- Phenotype
- Tumor Cells, Cultured