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Article

Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma.

The Journal of clinical investigation - 1 Dec 2011

Curiel-Lewandrowski Clara, Yamasaki Hisato, Si Chuan Ping, Jin Xiaoyi, Zhang Yujun, Richmond Jillian, Tuzova Marina, Wilson Kevin, Sullivan Beth, Jones David, Ryzhenko Nataliya, Little Frederick, Kupper Thomas S, Center David M, Cruikshank William W

Abstract excerpt

Cutaneous T cell lymphomas (CTCLs) represent a heterogeneous group of non-Hodgkin lymphomas that affect the skin. The pathogenesis of these conditions is poorly understood. For example, the signaling mechanisms contributing to the dysregulated growth of the neoplastic T cells are not well defined. Here, we demonstrate that loss of nuclear localization of pro-IL-16 facilitates CTCL cell proliferation by causing a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22080865
DOI: 10.1172/JCI41769
PMCID: PMC3225985

Genes

HSPA8

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