NLRP3 Regulates IL-4 Expression in TOX+ CD4+ T Cells of Cutaneous T Cell Lymphoma to Potentially Promote Disease Progression.

doi:10.3389/fimmu.2021.668369

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Article

NLRP3 Regulates IL-4 Expression in TOX+ CD4+ T Cells of Cutaneous T Cell Lymphoma to Potentially Promote Disease Progression.

Frontiers in immunology - 1 Jan 2021

Huanosta-Murillo Enrique, Alcántara-Hernández Marcela, Hernández-Rico Brenda, Victoria-Acosta Georgina, Miranda-Cruz Patricia, Domínguez-Gómez María Antonieta, Jurado-Santacruz Fermín, Patiño-López Genaro, Pérez-Koldenkova Vadim, Palma-Guzmán Alam, Licona-Limón Paula, Fuentes-Pananá Ezequiel M, Lemini-López Alicia, Bonifaz Laura C

Abstract excerpt

In cutaneous T cell lymphoma (CTCL), a dominant Th2 profile associated with disease progression has been proposed. Moreover, although the production and regulation of IL-4 expression during the early stages of the disease may have important implications in later stages, these processes are poorly understood. Here, we demonstrate the presence of TOX+ CD4+ T cells that produce IL-4+ in early-stage skin lesions of...

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Identifiers

PMID: 34220814
DOI: 10.3389/fimmu.2021.668369
PMCID: PMC8244903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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