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Article

Th17 cytokine differentiation and loss of plasticity after SOCS1 inactivation in a cutaneous T-cell lymphoma.

Oncotarget - 7 Jun 2016

Ehrentraut Stefan, Schneider Björn, Nagel Stefan, Pommerenke Claudia, Quentmeier Hilmar, Geffers Robert, Feist Maren, Kaufmann Maren, Meyer Corinna, Kadin Marshall E, Drexler Hans G, MacLeod Roderick A F

Abstract excerpt

We propose that deregulated T-helper-cell (Th) signaling underlies evolving Th17 cytokine expression seen during progression of cutaneous T-cell lymphoma (CTCL). Accordingly, we developed a lymphoma progression model comprising cell lines established at indolent (MAC-1) and aggressive (MAC-2A) CTCL stages. We discovered activating JAK3 (V722I) mutations present at indolent disease, reinforced in aggressive...

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Topics

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Share to Cell Differentiation
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Janus Kinase 3

Share to Lymphoma, T-Cell, Cutaneous

Share to STAT5 Transcription Factor

Share to Suppressor of Cytokine Signaling 1 Protein

Share to Th17 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 27144517
DOI: 10.18632/oncotarget.9077
PMCID: PMC5085149

Genes

JAK3
SOCS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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