Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rgs16 promotes antitumor CD8 + T cell exhaustion

27 May 2022

Abstract excerpt

T cells become functionally exhausted in tumors, limiting T cell–based immunotherapies. Although several transcription factors regulating the exhausted T (T ex ) cell differentiation are known, comparatively little is known about the regulators of T ex cell survival. Here, we reported that the regulator of G protein signaling 16 (Rgs-16) suppressed T ex cell survival in tumors. By performing lineage tracing using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35622904
DOI: 10.1126/sciimmunol.abh1873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rgs16 promotes antitumor CD8 + T cell exhaustionPMID 35622904Read ↗

Therapy-induced senescent-like cancer cells drive macrophage-mediated immunosuppression in cholangiocarcinomaSemantic proximity Read ↗

CD161, a promising Immune Checkpoint, correlates with Patient Prognosis: A Pan-cancer AnalysisSemantic proximity Read ↗

Rasal1 impairment unleashes anticancer immunity - a focus on T cellsSemantic proximity Read ↗

BCL11B targeting in tumor CD8 <sup>+</sup> T cells amplifies anti-tumor response by blocking exhaustion while promoting stemness and cytotoxicitySemantic proximity Read ↗

MLLT6 maintains PD‐L1 expression and mediates tumor immune resistanceSemantic proximity Read ↗

RIG-I is an intracellular checkpoint that limits CD8+ T-cell antitumor immunitySemantic proximity Read ↗

RGS16 promotes glioma progression and serves as a prognostic factorSemantic proximity Read ↗

Extracellular vesicle-mediated suppression of macrophage STING signaling promotes immune dysfunction in dedifferentiated liposarcomaSemantic proximity Read ↗

IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expressionSemantic proximity Read ↗

lnterleukin-16: The Ins and Outs of Regulating T-Cell ActivationSemantic proximity Read ↗

T-bet and Eomesodermin Are Required for T Cell-Mediated Antitumor Immune ResponsesSemantic proximity Read ↗

STING agonists drive recruitment and intrinsic type I interferon responses in monocytic lineage cells for optimal anti-tumor immunitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.